Mayo Clinic Diet vs Sequence: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
Sequence has the higher ClearScore (79 vs 78)
Mayo Clinic Diet is more affordable ($50/mo vs $99/mo)
Mayo Clinic Diet has higher ratings (4.4/5 vs 4.3/5)
Sequence scores better on value (4.4/5 vs 3.8/5)
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
Sequence
$99/mo
starting price
Specializes in getting brand-name GLP-1s covered by insurance. They handle prior authorization so you don't have to.
Mayo Clinic Diet vs Sequence: Full Comparison
| Mayo Clinic Diet | Sequence | |
|---|---|---|
| ClearScore | 78/100 | 79/100 ✓ |
| Overall Rating | 4.4/5 ✓ | 4.3/5 |
| Review Count | 98 ✓ | 96 |
| Starting Price | $50/mo ✓ | $99/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide | Branded Wegovy, Branded Zepbound, Branded Mounjaro, Branded Ozempic ✓ |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 1889 | 2021 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Sequence Programs
Insurance-Covered GLP-1
$99/mo + insurance copay
Medications: Branded Wegovy, Branded Zepbound, Branded Mounjaro, Branded Ozempic
- Insurance Navigation
- Prior Authorization
- Clinician Support
- Prescription Management
Ratings Breakdown
| Category | Mayo Clinic Diet | Sequence |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Sequence edges out Mayo Clinic Diet with a ClearScore of 79 vs 78. Mayo Clinic Diet is more affordable starting at $50/mo compared to $99/mo. For customer support, Sequence rates higher (4.5/5). The best choice depends on your priorities, medication preferences, and budget.