Mayo Clinic Diet vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Mayo Clinic Diet starts at $50/mo and SkyRx at $299/mo. Mayo Clinic Diet scores higher on our ClearScore (78 vs 75), and Mayo Clinic Diet is the cheaper starting option.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 75)
Mayo Clinic Diet is more affordable ($50/mo vs $299/mo)
Mayo Clinic Diet scores better on value (3.8/5 vs 3.6/5)
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
Mayo Clinic Diet vs SkyRx: Full Comparison
| Mayo Clinic Diet | SkyRx | |
|---|---|---|
| ClearScore | 78/100 ✓ | 75/100 |
| Overall Rating | 4.4/5 | 4.4/5 |
| Review Count | 98 ✓ | 58 |
| Starting Price | $50/mo ✓ | $299/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide ✓ | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 1889 | 2022 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | Mayo Clinic Diet | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out SkyRx with a ClearScore of 78 vs 75. Mayo Clinic Diet is more affordable starting at $50/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.