PlushCare vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
PlushCare starts at $20/mo and SkyRx at $299/mo. SkyRx scores higher on our ClearScore (70 vs 75), and PlushCare is the cheaper starting option.
Quick Verdict
SkyRx has the higher ClearScore (75 vs 70)
PlushCare is more affordable ($20/mo vs $299/mo)
SkyRx has higher ratings (4.4/5 vs 4/5)
PlushCare scores better on value (3.8/5 vs 3.6/5)
PlushCare
$20/mo
starting price
Full-service virtual primary care with board-certified doctors prescribing brand-name GLP-1s and insurance billing.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
PlushCare vs SkyRx: Full Comparison
| PlushCare | SkyRx | |
|---|---|---|
| ClearScore | 70/100 | 75/100 ✓ |
| Overall Rating | 4/5 | 4.4/5 ✓ |
| Review Count | 174 ✓ | 58 |
| Starting Price | $20/mo ✓ | $299/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide, Contrave ✓ | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2014 | 2022 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
PlushCare Programs
Weight Loss Program
$19.99/mo + consults + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Membership Access
- Prescription Discount Card
- Provider Messaging
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | PlushCare | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
SkyRx edges out PlushCare with a ClearScore of 75 vs 70. PlushCare is more affordable starting at $20/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.