Fifty 410 vs Mayo Clinic Diet: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 68)
Mayo Clinic Diet is more affordable ($50/mo vs $166/mo)
Fifty 410 has higher ratings (4.5/5 vs 4.4/5)
Fifty 410 scores better on value (4.3/5 vs 3.8/5)
Fifty 410
$166/mo
starting price
Multi-month discounts on tirzepatide. 4.9 Trustpilot rating (2,847 reviews). Uses 503A and 503B pharmacies.
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
Fifty 410 vs Mayo Clinic Diet: Full Comparison
| Fifty 410 | Mayo Clinic Diet | |
|---|---|---|
| ClearScore | 68/100 | 78/100 ✓ |
| Overall Rating | 4.5/5 ✓ | 4.4/5 |
| Review Count | 2,847 ✓ | 98 |
| Starting Price | $166/mo | $50/mo ✓ |
| Medications | Compounded Semaglutide, Compounded Tirzepatide | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide ✓ |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2023 | 1889 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Fifty 410 Programs
Semaglutide (4 weeks)
$199/mo
Medications: Compounded Semaglutide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (4 weeks)
$299/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (3-month plan)
From $166/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Ratings Breakdown
| Category | Fifty 410 | Mayo Clinic Diet |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out Fifty 410 with a ClearScore of 78 vs 68. Mayo Clinic Diet is more affordable starting at $50/mo compared to $166/mo. For customer support, Fifty 410 rates higher (4.5/5). The best choice depends on your priorities, medication preferences, and budget.