Fifty 410 vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
SkyRx has the higher ClearScore (75 vs 68)
Fifty 410 is more affordable ($166/mo vs $299/mo)
Fifty 410 has higher ratings (4.5/5 vs 4.4/5)
Fifty 410 scores better on value (4.3/5 vs 3.6/5)
Fifty 410
$166/mo
starting price
Multi-month discounts on tirzepatide. 4.9 Trustpilot rating (2,847 reviews). Uses 503A and 503B pharmacies.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
Fifty 410 vs SkyRx: Full Comparison
| Fifty 410 | SkyRx | |
|---|---|---|
| ClearScore | 68/100 | 75/100 ✓ |
| Overall Rating | 4.5/5 ✓ | 4.4/5 |
| Review Count | 2,847 ✓ | 58 |
| Starting Price | $166/mo ✓ | $299/mo |
| Medications | Compounded Semaglutide, Compounded Tirzepatide | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2023 | 2022 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Fifty 410 Programs
Semaglutide (4 weeks)
$199/mo
Medications: Compounded Semaglutide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (4 weeks)
$299/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (3-month plan)
From $166/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | Fifty 410 | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
SkyRx edges out Fifty 410 with a ClearScore of 75 vs 68. Fifty 410 is more affordable starting at $166/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.