Fifty 410 vs Sesame: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
Sesame has the higher ClearScore (74 vs 68)
Sesame is more affordable ($99/mo vs $166/mo)
Fifty 410 has higher ratings (4.5/5 vs 4.1/5)
Fifty 410
$166/mo
starting price
Multi-month discounts on tirzepatide. 4.9 Trustpilot rating (2,847 reviews). Uses 503A and 503B pharmacies.
Sesame
$99/mo
starting price
Wide medication selection with 14 options, insurance navigation support, and same-day consultations starting at $99/month.
Fifty 410 vs Sesame: Full Comparison
| Fifty 410 | Sesame | |
|---|---|---|
| ClearScore | 68/100 | 74/100 ✓ |
| Overall Rating | 4.5/5 ✓ | 4.1/5 |
| Review Count | 2,847 ✓ | 156 |
| Starting Price | $166/mo | $99/mo ✓ |
| Medications | Compounded Semaglutide, Compounded Tirzepatide | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide, Metformin, Contrave ✓ |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2023 | 2018 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Fifty 410 Programs
Semaglutide (4 weeks)
$199/mo
Medications: Compounded Semaglutide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (4 weeks)
$299/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (3-month plan)
From $166/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Sesame Programs
Success by Sesame
$99/mo + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Consultations
- Labs Included
- Insurance Navigation
- Same Day Appointments
Ratings Breakdown
| Category | Fifty 410 | Sesame |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Sesame edges out Fifty 410 with a ClearScore of 74 vs 68. Sesame is more affordable starting at $99/mo compared to $166/mo. For customer support, Fifty 410 rates higher (4.5/5). The best choice depends on your priorities, medication preferences, and budget.